In Zogen, a.k.a. ゾーゲン, the player researchers want to rid themselves of their microorganism cards as quickly as they can, but they can do so only by observing the current lab environment and watching the one thing that changes, then "recording" it by playing their card.

In more detail, each player starts with a hand of sixteen cards, with each card showing 0-4 types of microorganisms, which are named "Maru", "Tsuki", "Yama", and "Siri". The start player for the round places one of their cards face up on the table, then everyone plays at once, trying to lay down a card that differs from the initial card by exactly one microorganism, whether one more or one less.

Thus, if a card shows "Maru" and "Tsuki", you can lay down a card that shows either "Maru" or "Tsuki" or a card that shows "Maru" and "Tsuki" along with one of the previously missing microorganisms. You must say the name of the microorganism that is added or removed when you play a card, then everyone must match the card that you just played.

When a player has only three cards in hand, the round ends and players score points based on their rank in terms of how many cards they hold. Whoever has the most points after you've played the agreed-upon number of rounds wins.

在Zogen，又名ゾーゲン中，玩家研究人員希望盡快擺脫他們的微生物卡片，但他們只能通過觀察當前實驗室環境並觀察發生變化的事物來做到這一點，然後透過卡的運用來"紀錄"。

更詳細地說，每個玩家從一手 16 張牌開始，每張牌顯示 0-4 種微生物，分別命名為“Maru”、“Tsuki”、“Yama”和“Siri”。該輪的起始玩家將他們的一張牌面朝上放在桌子上，然後每個人同時玩，試圖放下一張與最初的牌只有一個微生物的牌，無論多一張還是少一張。

因此，如果一張卡片顯示“Maru”和“Tsuki”，您可以放下一張顯示“Maru”或“Tsuki”的卡片，或者一張顯示“Maru”和“Tsuki”的卡片以及之前缺失的微生物之一. 打牌時必須說出添加或去除的微生物的名稱，然後每個人都必須匹配您剛剛打出的牌。

當玩家手中只有三張牌時，回合結束，玩家根據他們持有多少張牌的排名得分。在您玩完商定的回合數後得分最多的人獲勝。